Understanding how immune cells remember infections to fight them better
Macrophage mitochodrial reprogramming and innate immune memory
This study is looking at how we can help certain immune cells in your body, called macrophages, remember past infections so they can better fight off future ones, especially for patients at risk of serious infections like those caught in hospitals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10774200 on NIH RePORTER |
What this research studies
This research investigates how certain immune cells, specifically macrophages, can be trained to remember past infections and respond more effectively to future threats. By using a treatment that activates these cells, the study aims to enhance the body's natural defenses against hospital-acquired infections and sepsis, which are significant health risks for patients. The approach involves administering TLR4 ligands to stimulate the immune system, potentially leading to improved outcomes for patients who are at risk of severe infections. The research focuses on the metabolic changes in macrophages that are crucial for developing this immune memory.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who are hospitalized and at risk of developing infections or sepsis.
Not a fit: Patients who are not hospitalized or those with conditions that do not involve immune system challenges may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapy treatments that significantly reduce the incidence and severity of hospital-acquired infections and sepsis.
How similar studies have performed: Previous studies have shown promising results with similar immunotherapy approaches, indicating potential for success in this area.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Sherwood, Edward R — Vanderbilt University Medical Center
- Study coordinator: Sherwood, Edward R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.