Understanding how immune cells remember infections in the gut
Impact of priming on the generation of intestinal tissue-resident memory T cells
['FUNDING_R01'] · STATE UNIVERSITY NEW YORK STONY BROOK · NIH-11127719
This research aims to discover how certain immune cells in the gut develop a 'memory' to better protect us from future infections and diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY NEW YORK STONY BROOK (nih funded) |
| Locations | 1 site (STONY BROOK, UNITED STATES) |
| Trial ID | NIH-11127719 on ClinicalTrials.gov |
What this research studies
Our bodies need strong immune defenses in the gut to fight off germs and even some cancers, but we don't fully understand how these protective memory cells are formed. This project explores the specific signals that teach immune cells, called CD8 T cells, to become long-lasting 'resident memory' cells in the intestine. By learning how these cells develop their memory, we hope to create more effective vaccines that can provide better protection where it's needed most.
Who could benefit from this research
Good fit: Patients who could potentially benefit from future applications of this research include those at risk for gut-related infections or certain types of cancer.
Not a fit: Patients seeking immediate treatment for existing conditions may not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to new and improved vaccines that offer stronger, longer-lasting protection against gut infections and certain cancers.
How similar studies have performed: Preliminary data supports the central idea, but this research addresses a critical gap in our current understanding of immune memory development.
Where this research is happening
STONY BROOK, UNITED STATES
- STATE UNIVERSITY NEW YORK STONY BROOK — STONY BROOK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHERIDAN, BRIAN S — STATE UNIVERSITY NEW YORK STONY BROOK
- Study coordinator: SHERIDAN, BRIAN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.