Understanding how immune cells protect hearing neurons from damage
Innate Immunity to Spiral Ganglion Neuron Degeneration
This study is looking at how certain immune cells help protect important hearing nerves after they've been damaged by loud noises, with the hope of finding new ways to treat hearing loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11085914 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the degeneration of spiral ganglion neurons (SGNs), which are crucial for hearing. It focuses on how immune cells communicate with these neurons to promote their survival after noise-induced injury. By studying the signaling pathways involved, particularly the role of fractalkine signaling, the research aims to uncover potential therapeutic targets for preserving hearing function. Patients may benefit from insights that could lead to new treatments for hearing loss.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals experiencing hearing loss due to noise exposure or other auditory trauma.
Not a fit: Patients with hearing loss not related to spiral ganglion neuron degeneration may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect or regenerate hearing neurons, improving outcomes for individuals with hearing loss.
How similar studies have performed: Previous research has shown promise in understanding immune cell interactions in neuroprotection, suggesting that this approach could yield significant insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Kaur, Tejbeer — Rutgers Biomedical and Health Sciences
- Study coordinator: Kaur, Tejbeer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.