Understanding how immune cells protect hair follicle stem cells
Elucidating the Role of Regulatory T cells in Protecting Epithelial Stem Cell Niches
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11101243
This study is looking at how certain immune cells can help protect the hair follicles from attacks that cause hair loss, like in alopecia, and it hopes to find new ways to treat these conditions for people who are struggling with hair growth issues.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11101243 on ClinicalTrials.gov |
What this research studies
This research investigates the role of regulatory T cells in protecting hair follicle stem cells from autoimmune attacks, which can lead to conditions like alopecia. The study employs a novel in vivo model that mimics severe forms of hair loss and utilizes innovative techniques to manipulate immune cells specifically in the skin. By examining the mechanisms of Treg localization and their protective functions, the research aims to uncover new insights into how these immune cells maintain the health of stem cells in the skin. Patients may benefit from a better understanding of autoimmune conditions affecting hair growth and potential new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing autoimmune-related hair loss, such as alopecia areata or scarring alopecia.
Not a fit: Patients with hair loss due to non-autoimmune causes or those without any hair loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune hair loss conditions, improving outcomes for affected patients.
How similar studies have performed: Other research has shown promising results in understanding the role of immune cells in skin health, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COHEN, JARISH NEWMAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: COHEN, JARISH NEWMAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.