Understanding how immune cells protect against tuberculosis
Harnessing activated CD4 T cells to define new mechanisms of protection in tuberculosis
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-11122267
This work explores how certain immune cells, called CD4 T cells, protect people from tuberculosis, aiming to find new ways to fight the infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11122267 on ClinicalTrials.gov |
What this research studies
Tuberculosis (TB) is a serious infection, and while CD4 T cells are known to be crucial for protection, we don't fully understand how they work. This project aims to identify the specific actions of these protective CD4 T cells in the lungs during TB infection. By using advanced techniques to study these cells, we hope to uncover new markers and functions that are key to a strong immune response. This deeper understanding could lead to more effective treatments or vaccines for TB.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with tuberculosis or those at risk of infection in the future.
Not a fit: Patients seeking immediate treatment for tuberculosis would not directly benefit from participating in this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new therapies or vaccines that enhance the body's natural defenses against tuberculosis.
How similar studies have performed: While the importance of CD4 T cells in TB is established, this approach uses novel techniques to pinpoint the specific activated cells responsible for protection, which is a relatively new area of focus.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOLD, TYLER DALLAS — UNIVERSITY OF MINNESOTA
- Study coordinator: BOLD, TYLER DALLAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.