Understanding how immune cells protect against cancer
Tissue Resident memory T cell responses to cancer
['FUNDING_R01'] · DARTMOUTH COLLEGE · NIH-11138773
This research explores how special immune cells called Trm cells help protect people from cancer, especially melanoma.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-11138773 on ClinicalTrials.gov |
What this research studies
Our bodies have special immune cells called Trm cells that live in tissues and act as a defense against cancer spreading. Previous work showed these cells protect against melanoma in mice and are found in human melanoma survivors for years. This project aims to understand how these protective Trm cells are formed and how they work in different parts of the body, particularly in lymph nodes. We want to learn more about the signals that help these cells develop and how they might offer a clinical benefit.
Who could benefit from this research
Good fit: This foundational research does not directly recruit patients, but future studies building on this work might seek individuals with melanoma or other cancers.
Not a fit: Patients not interested in basic immunology research or those without cancer would not directly benefit from this specific grant.
Why it matters
Potential benefit: If successful, this research could lead to new ways to boost the body's natural defenses against cancer, potentially preventing recurrence or metastasis.
How similar studies have performed: Previous work by this team has shown promising results in mice and identified similar immune cells in human melanoma survivors, suggesting a strong foundation for this approach.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TURK, MARY JO — DARTMOUTH COLLEGE
- Study coordinator: TURK, MARY JO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.