Understanding how immune cells present peptides related to autoimmune diseases
DYNAMICS AND TUNING OF THE MHC II PRESENTED PEPTIDOME
This study is looking at how certain immune cells in different parts of the body show pieces of proteins that might lead to autoimmune diseases like rheumatoid arthritis and multiple sclerosis, to help us understand why some people’s immune systems attack their own bodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10468682 on NIH RePORTER |
What this research studies
This research investigates how conventional dendritic cells (cDC) present peptides that can trigger autoimmune diseases, focusing on the variations in peptide presentation across different organs and conditions. By analyzing the MHC-II peptidome, the study aims to map how these peptides reflect the unique protein signatures of various organs. The researchers will use advanced mass spectrometry techniques to quantify changes in peptide abundance and composition, particularly in relation to self-antigens associated with conditions like rheumatoid arthritis and multiple sclerosis. This work could provide insights into the balance between immune tolerance and autoimmunity.
Who could benefit from this research
Good fit: Ideal candidates include individuals diagnosed with autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or type 1 diabetes.
Not a fit: Patients without autoimmune conditions or those not affected by the specific self-antigens being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding immune responses related to autoimmune diseases, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Santambrogio, Laura — Weill Medical Coll of Cornell Univ
- Study coordinator: Santambrogio, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.