Understanding how immune cells make decisions during inflammation
Microsystems to Decipher Leukocyte Decision-Making
This study is looking at how certain immune cells, called neutrophils, decide what to do when there's inflammation or infection, and it's for people with conditions like sepsis, aiming to find better ways to treat inflammatory diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Dallas NIH-funded |
| Lab location | 1 site (Richardson, United States) |
| Project ID | NIH-10655593 on NIH RePORTER |
What this research studies
This research investigates how innate immune cells, particularly neutrophils, make decisions regarding their activation and movement in response to inflammation and infection. By utilizing advanced microfluidic technologies, the study aims to quantify the different states of these cells in both healthy individuals and patients suffering from conditions like sepsis. The research combines experimental methods and modeling approaches to better understand the factors influencing immune cell behavior, which could lead to improved treatments for inflammatory diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with sepsis or other inflammatory syndromes, as well as healthy volunteers for comparative analysis.
Not a fit: Patients with non-inflammatory conditions or those not experiencing immune system challenges may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating sepsis and other inflammatory conditions by enhancing our understanding of immune cell behavior.
How similar studies have performed: Other research has shown promise in understanding immune cell behavior, but this approach utilizing microfluidic platforms is relatively novel.
Where this research is happening
Richardson, United States
- University of Texas Dallas — Richardson, United States (Active)
Researchers
- Principal investigator: Jones, Caroline N. — University of Texas Dallas
- Study coordinator: Jones, Caroline N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.