Understanding how immune cells interact with gut microbes
Integration of mononuclear phagocytes into the human gastrointestinal GOFlowChip for investigation of luminal antigen sampling
This study is looking at how immune cells in the gut react to germs and how the body decides when to fight them or let them be, using special 3-D models of gut cells to learn more about gut health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project ID | NIH-10694825 on NIH RePORTER |
What this research studies
This research focuses on developing advanced models of the human gastrointestinal tract to explore how immune cells respond to microbes and how the body can tolerate or activate immune responses. By creating 3-D cultures of gut cells and using a specialized platform called the GoFlowChip, researchers aim to study how immune cells sample antigens from the gut. This innovative approach combines bioengineering and immunology to better understand the interactions between gut microbes and the immune system, which could lead to new insights into gastrointestinal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal disorders or those interested in understanding immune responses related to gut health.
Not a fit: Patients with non-gastrointestinal related conditions or those not interested in immune system interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of gastrointestinal diseases and immune-related conditions.
How similar studies have performed: Other research has shown promise in using organoid models to study gut health, indicating that this approach could yield valuable insights.
Where this research is happening
Bozeman, United States
- Montana State University - Bozeman — Bozeman, United States (Active)
Researchers
- Principal investigator: Walk, Seth T — Montana State University - Bozeman
- Study coordinator: Walk, Seth T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.