Understanding how immune cells interact in germinal centers of macaques
Official title: Tracing spatial organization of germinal centers in rhesus macaques
Funded at Georgia Institute of Technology · NIH-10907786 · Data updated 2026-11-12
This study is looking at how certain immune cells work together in the bodies of rhesus macaques to help us understand how HIV affects the immune system, which could lead to better treatments for people with AIDS.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $316,400 |
| NIH project number | 5R21OD035574-02 |
| Project ID | NIH-10907786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals affected by HIV/AIDS, particularly those experiencing immune deficiencies.
✕Less likely to help
Patients who are not affected by HIV/AIDS or those with other unrelated health conditions may not receive any benefit from this research.
What this research studies
This research investigates the spatial organization of germinal centers in rhesus macaques, which are important for understanding immune responses in AIDS. By examining the interactions between various immune cells, such as B cells and T cells, and their surrounding environment, the study aims to uncover how these interactions are affected by HIV infection. The researchers will use advanced techniques like spatial proteomic and transcriptional profiling to analyze these cellular interactions at a single-cell level. This work could provide insights into the immune deficiencies seen in AIDS patients and inform future therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of immune responses in AIDS, potentially guiding the development of more effective treatments.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in understanding immune responses in other contexts, suggesting potential for success.
Where this research is happening
-
Georgia Institute of Technology
Atlanta, United States Active
Researchers
- Principal investigator: Coskun, Ahmet F. — Georgia Institute of Technology
- Study coordinator: Coskun, Ahmet F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.