Understanding how immune cells interact in brucellosis
B Cell/T Cell Interactions in Brucellosis
['FUNDING_R01'] · MONTANA STATE UNIVERSITY - BOZEMAN · NIH-11182048
This study is looking at how certain immune cells called B cells and T cells work together in people with brucellosis, a bacterial infection that can cause long-lasting symptoms, to find out why some patients don’t get better even after treatment, with the hope of discovering new ways to improve vaccines and treatments for everyone affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MONTANA STATE UNIVERSITY - BOZEMAN (nih funded) |
| Locations | 1 site (BOZEMAN, UNITED STATES) |
| Trial ID | NIH-11182048 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between B cells and T cells in the context of brucellosis, a bacterial infection that can lead to chronic illness. The study aims to uncover how B cells may hinder the immune response by affecting T cell function, which could explain why some patients experience persistent symptoms despite treatment. By exploring the mechanisms of B cell antigen presentation and its impact on T cell differentiation, the research seeks to identify new strategies for improving vaccine efficacy and managing the disease. Patients may benefit from insights that could lead to better treatment options and potential vaccine development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with brucellosis who are experiencing chronic symptoms despite antibiotic treatment.
Not a fit: Patients with brucellosis who have already recovered or those without a confirmed diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and vaccines for brucellosis, reducing the burden of chronic illness for affected patients.
How similar studies have performed: Previous research has shown promise in understanding immune interactions in other chronic infections, suggesting that this approach may yield valuable insights.
Where this research is happening
BOZEMAN, UNITED STATES
- MONTANA STATE UNIVERSITY - BOZEMAN — BOZEMAN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SKYBERG, JEROD — MONTANA STATE UNIVERSITY - BOZEMAN
- Study coordinator: SKYBERG, JEROD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.