Understanding how immune cells interact in brucellosis
Official title: B Cell/T Cell Interactions in Brucellosis
Funded at Montana State University - Bozeman · NIH-11182048 · Data updated 2026-11-12
This study is looking at how certain immune cells called B cells and T cells work together in people with brucellosis, a bacterial infection that can cause long-lasting symptoms, to find out why some patients don’t get better even after treatment, with the hope of discovering new ways to improve vaccines and treatments for everyone affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project start | November 18, 2020 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $351,625 |
| NIH project number | 7R01AI150797-05 |
| Project ID | NIH-11182048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with brucellosis who are experiencing chronic symptoms despite antibiotic treatment.
✕Less likely to help
Patients with brucellosis who have already recovered or those without a confirmed diagnosis may not benefit from this research.
What this research studies
This research investigates the interactions between B cells and T cells in the context of brucellosis, a bacterial infection that can lead to chronic illness. The study aims to uncover how B cells may hinder the immune response by affecting T cell function, which could explain why some patients experience persistent symptoms despite treatment. By exploring the mechanisms of B cell antigen presentation and its impact on T cell differentiation, the research seeks to identify new strategies for improving vaccine efficacy and managing the disease. Patients may benefit from insights that could lead to better treatment options and potential vaccine development.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and vaccines for brucellosis, reducing the burden of chronic illness for affected patients.
How similar studies have gone: Previous research has shown promise in understanding immune interactions in other chronic infections, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Montana State University - Bozeman
Bozeman, United States Active
Researchers
- Principal investigator: Skyberg, Jerod — Montana State University - Bozeman
- Study coordinator: Skyberg, Jerod
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.