Understanding how immune cells interact in Alzheimer's disease
Crosstalk between innate-immunity human microglia and adaptive-immunity Tregs in Alzheimer's disease
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11113938
This study is looking at how two types of immune cells in the brain talk to each other in Alzheimer's disease, hoping to learn more about how this communication affects inflammation and could lead to new treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11113938 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between two types of immune cells, microglia and Tregs, in the context of Alzheimer's disease. It aims to understand how these cells communicate and how this communication affects neuroinflammation, which is a key feature of Alzheimer's. By examining the effects of glutamate on Tregs, the study seeks to uncover new insights into how these immune responses may influence the progression of Alzheimer's disease. Patients may benefit from a better understanding of the disease mechanisms, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are experiencing symptoms of Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or slow the progression of Alzheimer's disease.
How similar studies have performed: While the specific interactions being studied are novel, previous research has shown that understanding immune responses can lead to significant advancements in treating neurodegenerative diseases.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIPTON, STUART A — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: LIPTON, STUART A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.