Understanding how immune cells influence pancreatic cancer development
Official title: Mechanisms of myeloid cell driven pancreatic plasticity and carcinogenesis
Funded at University of Michigan at Ann Arbor · NIH-11009903 · Data updated 2026-11-12
This study is looking at how certain immune cells in the body might help or hurt the growth of pancreatic cancer, using special mouse models that act like human cases, to better understand how these cells interact with the cancer and the surrounding tissue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $640,945 |
| NIH project number | 5R01CA268426-03 |
| Project ID | NIH-11009903 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk for pancreatic cancer, including those with genetic predispositions or early-stage pancreatic lesions.
✕Less likely to help
Patients with advanced pancreatic cancer who are not responding to current treatments may not benefit from this research.
What this research studies
This research investigates the role of myeloid cells, a type of immune cell, in the development and progression of pancreatic cancer. By using genetically engineered mouse models that mimic human pancreatic cancer, the study aims to explore how these immune cells interact with cancer cells and the surrounding tissue environment. The researchers will examine how myeloid cells can both promote cancer growth and support tissue repair, providing insights into the complex dynamics of pancreatic cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target myeloid cells to improve treatment outcomes for pancreatic cancer patients.
How similar studies have gone: Previous research has shown that targeting immune cell interactions can lead to significant advancements in cancer treatment, indicating potential success for this approach.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Pasca Di Magliano, Marina — University of Michigan at Ann Arbor
- Study coordinator: Pasca Di Magliano, Marina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.