Understanding how immune cells in the lungs respond to tuberculosis infection
Macrophage nuclear receptors, metabolism and immune effectors during health and M. tuberculosis infection
This study is looking at how a special type of immune cell in your lungs helps fight infections like tuberculosis, especially when influenced by things like pollution and allergens, to find new ways to treat lung infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10457308 on NIH RePORTER |
What this research studies
This research investigates the role of alveolar macrophages, a type of immune cell in the lungs, in responding to infections like tuberculosis. It aims to uncover how these cells develop and function in the presence of environmental factors such as pollutants and allergens. By studying the signaling pathways and molecular mechanisms involved, the research seeks to identify potential new treatment strategies for tuberculosis. Patients may benefit from insights that could lead to improved therapies for lung infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of tuberculosis or those at high risk for lung infections.
Not a fit: Patients with non-respiratory conditions or those not at risk for tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for tuberculosis and other lung infections.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to lung infections, indicating potential for success in this area.
Where this research is happening
San Antonio, United States
- Texas Biomedical Research Institute — San Antonio, United States (Active)
Researchers
- Principal investigator: Schlesinger, Larry S. — Texas Biomedical Research Institute
- Study coordinator: Schlesinger, Larry S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.