Understanding how immune cells in the lungs affect HIV persistence and inflammation in people living with HIV.
Official title: Investigating alveolar macrophages in PLWH as targets for HIV persistence, residual inflammation and immune activation
Funded at Emory University · NIH-10898374 · Data updated 2026-11-12
This study is looking at how certain immune cells in the lungs of people with HIV, who are taking medication to manage the virus, might be causing ongoing inflammation and affecting their health, with the goal of finding new ways to improve treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 19, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,010,290 |
| NIH project number | 1R01AI183455-01 |
| Project ID | NIH-10898374 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates the role of alveolar macrophages, a type of immune cell in the lungs, in people living with HIV who are on antiretroviral therapy. It aims to understand how these cells contribute to ongoing inflammation and immune activation, which can hinder efforts to eradicate HIV. The study will analyze samples from the lungs of participants to explore how these macrophages respond to HIV and other respiratory infections. By identifying the mechanisms involved, the research seeks to uncover potential new targets for treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing HIV and reducing inflammation in patients, potentially enhancing their overall health and quality of life.
How similar studies have gone: Previous research has shown promise in understanding immune responses in HIV, but this specific focus on alveolar macrophages is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Rengarajan, Jyothi — Emory University
- Study coordinator: Rengarajan, Jyothi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.