Understanding how immune cells in the brain change with aging and Alzheimer's disease
Official title: Major Histocompatibility Complex I regulation of microglial function in aging and Alzheimer's Disease
Funded at Oklahoma Medical Research Foundation · NIH-10985578 · Data updated 2026-11-12
This study looks at how brain immune cells called microglia change as we age and how these changes might affect Alzheimer's disease, with the goal of finding new ways to understand and possibly improve brain health for those with the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,027,220 |
| NIH project number | 1RF1AG085573-01A1 |
| Project ID | NIH-10985578 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or are at risk for developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of microglia, the brain's immune cells, in aging and Alzheimer's disease. It focuses on how these cells change their behavior over time and how this affects the development and progression of Alzheimer's. The study examines specific receptors on microglia that may influence their activity and contribute to either protecting or harming brain health. By exploring these mechanisms, the research aims to uncover new insights into neuroinflammation and its impact on Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance brain health and slow the progression of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of microglia in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Freeman, Willard M — Oklahoma Medical Research Foundation
- Study coordinator: Freeman, Willard M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.