Understanding how immune cells in the abdomen respond to bacterial infections in cirrhosis patients
Role of Peritoneal Macrophage in Spontaneous Bacterial Peritonitis
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-10877921
This study is looking at how certain immune cells in the abdomen help fight off infections in people with cirrhosis who might develop a serious condition called spontaneous bacterial peritonitis, with the goal of finding better ways to treat this infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-10877921 on ClinicalTrials.gov |
What this research studies
This research investigates the role of peritoneal macrophages, a type of immune cell found in the abdomen, in the development of spontaneous bacterial peritonitis (SBP), a serious infection that can occur in patients with cirrhosis. The study aims to understand how these immune cells respond to bacterial infections and whether cirrhosis affects their ability to fight off these infections. By using animal models, researchers will explore the mechanisms behind the immune response and the potential for developing new treatment strategies to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cirrhosis who are at risk of developing spontaneous bacterial peritonitis.
Not a fit: Patients without cirrhosis or those who do not have a risk of bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new management strategies for preventing and treating spontaneous bacterial peritonitis in patients with cirrhosis.
How similar studies have performed: Previous research has shown that understanding immune responses in similar contexts can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAITO, TAKESHI — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: SAITO, TAKESHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.