Understanding how immune cells in the abdomen respond to bacterial infections in cirrhosis patients
Official title: Role of Peritoneal Macrophage in Spontaneous Bacterial Peritonitis
Funded at University of Southern California · NIH-10877921 · Data updated 2026-11-12
This study is looking at how certain immune cells in the abdomen help fight off infections in people with cirrhosis who might develop a serious condition called spontaneous bacterial peritonitis, with the goal of finding better ways to treat this infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $536,389 |
| NIH project number | 5R01AI179019-02 |
| Project ID | NIH-10877921 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cirrhosis who are at risk of developing spontaneous bacterial peritonitis.
✕Less likely to help
Patients without cirrhosis or those who do not have a risk of bacterial infections may not benefit from this research.
What this research studies
This research investigates the role of peritoneal macrophages, a type of immune cell found in the abdomen, in the development of spontaneous bacterial peritonitis (SBP), a serious infection that can occur in patients with cirrhosis. The study aims to understand how these immune cells respond to bacterial infections and whether cirrhosis affects their ability to fight off these infections. By using animal models, researchers will explore the mechanisms behind the immune response and the potential for developing new treatment strategies to improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new management strategies for preventing and treating spontaneous bacterial peritonitis in patients with cirrhosis.
How similar studies have gone: Previous research has shown that understanding immune responses in similar contexts can lead to significant advancements in treatment, suggesting potential success for this approach.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Saito, Takeshi — University of Southern California
- Study coordinator: Saito, Takeshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.