Understanding how immune cells help heal inflammation in the mouth
The role of tissue-resident T cells in resolving inflammation of the human oral mucosa
This study is looking at how certain immune cells called T cells help control inflammation in the gums, which is important for healing, and it aims to find out why these cells sometimes struggle to do their job, so we can improve treatment for gum issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10625076 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, particularly T cells, in managing inflammation within the oral mucosa, which is crucial for healing and tissue repair. By examining chronically inflamed gum tissues, the study aims to understand how these T cells can either promote healing or contribute to ongoing inflammation. The researchers will explore various mechanisms that may hinder the ability of these T cells to resolve inflammation effectively. This could lead to new insights into how to better manage oral inflammatory conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic oral inflammation or related conditions.
Not a fit: Patients without any history of oral inflammation or those with acute, non-chronic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for inflammatory conditions affecting the oral mucosa, enhancing healing and reducing tissue damage.
How similar studies have performed: Previous research has shown promise in understanding the role of immune cells in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Prlic, Martin — Fred Hutchinson Cancer Center
- Study coordinator: Prlic, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.