Understanding how immune cells fight tuberculosis
Understanding early macrophage-T cell interactions, SLAMF1, and immunity to TB
This research explores how specific immune cells, called macrophages and T cells, work together to protect against tuberculosis, a serious lung infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11128668 on NIH RePORTER |
What this research studies
Tuberculosis (TB) is a dangerous infection that first affects immune cells called alveolar macrophages in the lungs. While T cells are known to help macrophages control TB, we don't fully understand how they communicate. This project aims to discover how these immune cells interact at the very beginning of an infection. We found a special marker, SLAMF1, on infected macrophages that shows they have talked to T cells, which helps us identify the key cells involved. By understanding these early interactions, we hope to find new ways to boost the body's natural defenses against TB.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this work might seek individuals with tuberculosis or those at risk of infection.
Not a fit: Patients not affected by tuberculosis or related immune system challenges would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for vaccines or treatments that strengthen the immune system's ability to fight tuberculosis.
How similar studies have performed: While the role of T cells and macrophages in TB is known, identifying SLAMF1 as a marker for early, protective interactions is a novel aspect of this approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Philips, Jennifer a — Washington University
- Study coordinator: Philips, Jennifer a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.