Understanding how immune cells fight Toxoplasma gondii infection
Official title: Role of reactive oxygen species in controlling T. gondii acute infection
Funded at California State Poly U Pomona · NIH-10937010 · Data updated 2026-11-12
This study looks at how certain immune cells in our body fight off the Toxoplasma gondii parasite, which can make some people very sick, and aims to learn more about how these cells work so we can find better ways to help those who are affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California State Poly U Pomona NIH-funded |
| Lab location | 1 site (Pomona, United States) |
| Project start | July 24, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $176,537 |
| NIH project number | 1R16AI184345-01 |
| Project ID | NIH-10937010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are immunocompromised or pregnant, as they are at higher risk for severe complications from T. gondii infection.
✕Less likely to help
Patients who are healthy and have no risk factors for severe toxoplasmosis may not benefit from this research.
What this research studies
This research investigates how human immune cells, specifically neutrophils, respond to the Toxoplasma gondii parasite, which can cause serious illness in some individuals. The study aims to uncover the mechanisms by which these immune cells produce reactive oxygen species (ROS) to combat the infection. By examining the cellular events and receptors involved in this process, the research seeks to enhance our understanding of the immune response to T. gondii. This knowledge could lead to improved therapeutic strategies for those affected by this parasite.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for toxoplasmosis, particularly for vulnerable populations such as immunocompromised individuals and pregnant women.
How similar studies have gone: Previous research has shown that understanding immune responses to infections can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
-
California State Poly U Pomona
Pomona, United States Active
Researchers
- Principal investigator: Lima, Tatiane S. — California State Poly U Pomona
- Study coordinator: Lima, Tatiane S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.