Understanding how immune cells die and cause inflammation
Official title: Innate immune receptor driven programmed necrosis is coupled to hyper-synthesis of inflammatory lipid mediators in host defense
Funded at University of Maryland Baltimore · NIH-11091461 · Data updated 2026-11-12
This study is looking at how certain immune cells die in a way that helps our body fight infections and heal injuries, and it hopes to find new ways to manage inflammation in different diseases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 17, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $194,375 |
| NIH project number | 5R21AI180181-02 |
| Project ID | NIH-11091461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from conditions associated with excessive inflammation or immune responses.
✕Less likely to help
Patients with stable, non-inflammatory conditions may not receive any benefit from this research.
What this research studies
This research investigates how innate immune cells respond to infections and injuries by undergoing a specific type of programmed cell death called necroptosis. It aims to understand the mechanisms that link this cell death to the production of inflammatory lipid mediators, which are crucial for fighting infections and healing. By studying these processes, the research seeks to identify potential therapeutic targets that could help control excessive inflammation in various diseases. The approach includes both laboratory experiments and in vivo studies to explore these connections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation in diseases characterized by uncontrolled immune responses.
How similar studies have gone: Previous research has shown promising results in understanding the role of programmed cell death in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Perkins, Darren — University of Maryland Baltimore
- Study coordinator: Perkins, Darren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.