Understanding how immune cells develop in the female reproductive tract
Interrogating mucosal resident memory CD8 T cell biology with 3D organoids
['FUNDING_R21'] · BROWN UNIVERSITY · NIH-11092856
This study is looking at how certain immune cells in the female reproductive system help protect against viruses, using a special lab model that mimics the vaginal environment, to find ways to boost women's defenses against infections.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11092856 on ClinicalTrials.gov |
What this research studies
This research investigates the biology of resident memory CD8 T cells in the female reproductive tract, which play a crucial role in protecting against viral infections. By using a three-dimensional organoid model that mimics the vaginal environment, researchers aim to uncover the molecular signals that guide the differentiation of these immune cells. The study involves culturing these organoids with CD8 T cells to observe how they develop and respond to potential threats. This approach could lead to a better understanding of how to enhance antiviral immunity in women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who are interested in understanding immune responses in the reproductive system, particularly those at risk for viral infections.
Not a fit: Patients who do not have a female reproductive tract or those who are not at risk for viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve strategies for preventing and treating viral infections in the female reproductive tract.
How similar studies have performed: Previous research has shown promise in using organoid models to study immune cell behavior, indicating that this approach could yield valuable insights.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEURA, LALIT K — BROWN UNIVERSITY
- Study coordinator: BEURA, LALIT K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.