Understanding how immune cells develop in joint tissues
Development of resident memory T cells in the synovium
['FUNDING_CAREER'] · BOSTON CHILDREN'S HOSPITAL · NIH-11058370
This study is looking at special immune cells in the joints of people with rheumatoid arthritis and juvenile idiopathic arthritis to find out how they work and stick around, with the hope of discovering new ways to help manage arthritis flare-ups and improve your overall health.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11058370 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific immune cells, known as resident memory T cells, in the joints of patients with rheumatoid arthritis and juvenile idiopathic arthritis. By studying both mouse models and human tissue samples, the researchers aim to uncover how these cells develop and persist in the synovium, which is the tissue lining the joints. The goal is to identify potential new targets for therapy that could help manage arthritis flares and improve patient outcomes. This work combines advanced techniques in immunology and bioengineering to better understand the disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis or juvenile idiopathic arthritis who experience periodic arthritis flares.
Not a fit: Patients with other types of arthritis or those without autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the immune cells responsible for arthritis flares, potentially reducing symptoms and improving quality of life for patients.
How similar studies have performed: Previous research has shown promise in targeting immune cells in autoimmune diseases, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANG, MARGARET — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: CHANG, MARGARET
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.