Understanding how immune cells decide their roles in cancer
Dissecting the enhancer logic governing immune cell fate decisions
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10472872
This study is looking at how certain immune cells called CD8 T cells decide what to do when they’re in different types of cancer, like melanoma and liver cancer, to help find better ways to boost cancer treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10472872 on ClinicalTrials.gov |
What this research studies
This research investigates how CD8 T cells, which play a vital role in fighting tumors, make decisions about their function and fate in different cancer environments. By examining the epigenetic mechanisms that influence these decisions, the study aims to identify the specific signals that guide T cell behavior in cancers like melanoma and hepatocellular carcinoma. The researchers will use advanced techniques to manipulate these signals and observe the effects on T cell differentiation in real-time. This could lead to new insights into improving cancer immunotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with melanoma or hepatocellular carcinoma who are undergoing treatment.
Not a fit: Patients with cancers other than melanoma or hepatocellular carcinoma may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of immunotherapies for cancer patients by providing a deeper understanding of T cell behavior in tumors.
How similar studies have performed: Previous research has shown promising results in understanding T cell dynamics in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEN, DEBATTAMA RAI — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: SEN, DEBATTAMA RAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer