Understanding how immune cells control gene expression to prevent autoimmunity
Elucidating Lymphocyte Allelic Exclusion Mechanisms and Functions
This study is looking at how certain immune cells, called T and B lymphocytes, make sure they only use one type of receptor to recognize germs, which helps prevent autoimmune diseases and might even help stop cancer in these cells, and the findings could lead to better understanding and treatments for patients with immune system issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10684807 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind allelic exclusion in T and B lymphocytes, which is crucial for ensuring that these immune cells express only one type of antigen receptor. By studying how this process prevents autoimmunity and potentially suppresses cancerous changes in immune cells, the research aims to fill significant knowledge gaps. The approach involves using genetically modified mice to explore the effects of altering gene expression patterns without disrupting overall immune cell development. Patients may benefit from insights gained into immune system functioning and the prevention of autoimmune diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with autoimmune disorders or those at risk for developing such conditions.
Not a fit: Patients with non-autoimmune related conditions or those not affected by immune system dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing autoimmune diseases and improving immune responses in patients.
How similar studies have performed: Previous research has shown promising results in understanding immune cell gene expression, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Bassing, Craig H — Children's Hosp of Philadelphia
- Study coordinator: Bassing, Craig H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.