Understanding how immune cells contribute to nerve damage in multiple sclerosis
Epigenomic regulation of oxidative stress-producing innate immunity in neuroinflammation
This study is looking at how stress in the body affects the immune system and can cause nerve damage in people with multiple sclerosis, with the hope of finding new ways to help treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11039918 on NIH RePORTER |
What this research studies
This research investigates the role of oxidative stress in the immune response that leads to nerve damage in conditions like multiple sclerosis (MS). It focuses on how the epigenome, which regulates gene activity, influences the behavior of immune cells that produce harmful oxidative stress. By using advanced techniques to analyze the genetic and epigenetic factors involved, the study aims to uncover new therapeutic targets that could help mitigate neurodegeneration caused by immune responses. Patients may benefit from insights that could lead to novel treatments for MS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis or related neuroinflammatory conditions.
Not a fit: Patients with neurological disorders not related to oxidative stress or immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce nerve damage in patients with multiple sclerosis.
How similar studies have performed: Other research has shown promising results in understanding the role of the epigenome in immune responses, suggesting that this approach could yield significant insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Mendiola, Andrew S — University of California, San Diego
- Study coordinator: Mendiola, Andrew S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.