Understanding how immune cells contribute to kidney stone formation
Renal macrophages in the pathogenesis of human urinary stones and Randall's plaque formation in mice
This study is looking at how certain immune cells in the kidneys might contribute to the formation of urinary stones, with the hope of finding new ways to prevent this painful condition and improve treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10839865 on NIH RePORTER |
What this research studies
This research investigates the role of renal macrophages, a type of immune cell, in the development of urinary stones. By studying both human tissues and mouse models, the researchers aim to uncover how these cells interact with kidney crystals and influence inflammation. The project focuses on identifying specific biomarkers and cellular responses that could lead to better prevention strategies for urinary stone disease. Patients may benefit from insights that could lead to new treatments or preventive measures for this painful condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of urinary stone formation or those experiencing related symptoms.
Not a fit: Patients who do not have urinary stone disease or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for patients suffering from urinary stone disease.
How similar studies have performed: Previous research has shown promising results in understanding the immune response in kidney stone formation, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Lieske, John C — Mayo Clinic Rochester
- Study coordinator: Lieske, John C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.