Understanding how immune cells contribute to inflammatory arthritis
Official title: Immune cell contributions to inflammatory arthritis
Funded at Vanderbilt University Medical Center · NIH-11072806 · Data updated 2026-11-12
This study is looking at how certain immune cells, especially B cells, affect the inflammation and joint damage in people with psoriatic arthritis, using a special mouse model to help find better treatments that could improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 10, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $735,460 |
| NIH project number | 1R01AR084312-01A1 |
| Project ID | NIH-11072806 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with psoriatic arthritis who are experiencing significant symptoms.
✕Less likely to help
Patients with other forms of arthritis or those who do not have psoriatic arthritis may not benefit from this research.
What this research studies
This research investigates the role of immune cells, particularly B cells, in the development and progression of psoriatic arthritis (PsA). By utilizing a specially engineered mouse model that mimics human PsA, the study aims to uncover how different immune cells interact and contribute to inflammation and joint damage. The research will explore the effects of existing treatments and identify potential new therapeutic targets to improve patient outcomes. Patients may benefit from insights gained about the immune mechanisms driving their condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for psoriatic arthritis, potentially reducing symptoms and improving quality of life for patients.
How similar studies have gone: Previous studies have shown that targeting B cells can improve clinical outcomes in psoriatic arthritis, indicating that this approach has potential for success.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Ward, Nicole Leanne — Vanderbilt University Medical Center
- Study coordinator: Ward, Nicole Leanne
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.