Understanding how immune cells contribute to endometriosis
Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification
This study is looking at how immune cells interact with tissue similar to the lining of the uterus in women with endometriosis, a condition that causes painful symptoms and can affect fertility, to help find better ways to diagnose and treat it.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10900786 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between immune cells and endometrial-like tissue in women with endometriosis, a condition that causes severe pelvic pain and infertility. By utilizing advanced single-cell technologies, the study aims to analyze the cellular makeup of endometriosis lesions and the immune responses involved. The goal is to develop a better understanding of the disease's pathobiology, which could lead to improved diagnostic methods and targeted therapies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are women of reproductive age who are experiencing symptoms of endometriosis, such as pelvic pain or infertility.
Not a fit: Patients who do not have endometriosis or those who are not experiencing related symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and effective treatments for women suffering from endometriosis.
How similar studies have performed: Previous research has shown promise in using single-cell technologies to understand complex diseases, suggesting that this approach could yield valuable insights into endometriosis.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Giudice, Linda C — University of California, San Francisco
- Study coordinator: Giudice, Linda C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.