Understanding how immune cells contribute to autoimmune diseases
Regulators of immune complex mediated neutrophil antigen presentation
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11040307
This research explores how certain immune cells called neutrophils might worsen autoimmune diseases, especially those that affect the kidneys.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11040307 on ClinicalTrials.gov |
What this research studies
Autoimmune diseases, which affect millions of Americans, happen when the body's immune system mistakenly attacks its own healthy tissues. This project focuses on immune cells called neutrophils, specifically how they can transform into powerful antigen-presenting cells (nAPCs) when they encounter immune complexes. These nAPCs are similar to other immune cells known to trigger strong immune responses, and early findings suggest they might play a role in autoimmune conditions like lupus. By understanding how these nAPCs work, we hope to find new ways to help patients with these challenging diseases.
Who could benefit from this research
Good fit: This foundational research is relevant to patients living with autoimmune diseases, particularly those experiencing kidney involvement such as ANCA vasculitis or lupus nephritis.
Not a fit: Individuals without autoimmune conditions or those whose conditions are not related to the immune mechanisms being studied would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target these specific immune cells to reduce inflammation and damage in autoimmune diseases.
How similar studies have performed: This project builds upon recent findings that show neutrophils can act as antigen-presenting cells, representing a new direction in understanding their role in autoimmune disorders.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAYADAS, TANYA N — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: MAYADAS, TANYA N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.