Understanding how immune cells communicate to heal the heart after a heart attack
A dialogue between neutrophils and monocytes for effective resolution of inflammation following acute myocardial injury
This study is looking at how certain immune cells in your body work together after a heart attack to help with healing and reduce inflammation, with the goal of finding better ways to support recovery for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10865131 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between neutrophils and monocytes following a heart attack, focusing on how these immune cells contribute to inflammation and healing. By analyzing the behavior of these cells in the heart, the study aims to uncover mechanisms that could lead to better management of inflammation, which is crucial for recovery. The researchers utilize advanced techniques like RNA sequencing to explore the genetic changes in immune cells during the healing process. This could help identify new therapeutic targets to improve patient outcomes after myocardial infarction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a myocardial infarction.
Not a fit: Patients who have not had a heart attack or those with chronic heart conditions unrelated to acute myocardial injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance heart healing and reduce the risk of heart failure after a heart attack.
How similar studies have performed: Previous research has shown promising results in understanding immune cell interactions in other inflammatory conditions, suggesting potential for success in this novel approach.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Nagareddy, Prabhakara Reddy — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Nagareddy, Prabhakara Reddy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.