Understanding how immune cells communicate to heal the heart after a heart attack
Official title: A dialogue between neutrophils and monocytes for effective resolution of inflammation following acute myocardial injury
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10865131 · Data updated 2026-11-12
This study is looking at how certain immune cells in your body work together after a heart attack to help with healing and reduce inflammation, with the goal of finding better ways to support recovery for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $557,857 |
| NIH project number | 5R01HL156856-04 |
| Project ID | NIH-10865131 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a myocardial infarction.
✕Less likely to help
Patients who have not had a heart attack or those with chronic heart conditions unrelated to acute myocardial injury may not benefit from this research.
What this research studies
This research investigates the complex interactions between neutrophils and monocytes following a heart attack, focusing on how these immune cells contribute to inflammation and healing. By analyzing the behavior of these cells in the heart, the study aims to uncover mechanisms that could lead to better management of inflammation, which is crucial for recovery. The researchers utilize advanced techniques like RNA sequencing to explore the genetic changes in immune cells during the healing process. This could help identify new therapeutic targets to improve patient outcomes after myocardial infarction.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance heart healing and reduce the risk of heart failure after a heart attack.
How similar studies have gone: Previous research has shown promising results in understanding immune cell interactions in other inflammatory conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Nagareddy, Prabhakara Reddy — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Nagareddy, Prabhakara Reddy
Related research
Other NIH-funded projects on the same topics.
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Neutrophil-monocyte communication to improve heart healing after a heart attack
A patient-centered look at how white blood cells talk to each other after a heart attack to help the heart heal better.
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Understanding how to care for heart injury during sepsis
This study looks at how doctors evaluate and treat heart injury that can happen when sepsis occurs, using real patient records to find better, more actionable care patterns.
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How a new PET tracer spots heart scarring
This project looks at whether a PET tracer made from FDG can reveal early scarring in injured hearts.
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Different types of heart attacks and other heart muscle injuries in a long-term, diverse community cohort
Using 14 years of MESA data, the team will reclassify heart attacks and non-ischemic heart muscle injuries to link each type to different risk factors.
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Improving care for heart injury during sepsis
This project aims to find better ways to understand and treat heart muscle injury that can happen when someone has sepsis.
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How neutrophils and monocytes coordinate to help the heart heal after a heart attack
The team is learning how early immune cells (neutrophils and monocytes) clear damage and calm inflammation after a heart attack to improve healing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.