Understanding how immune cells behave to improve cell therapies
Official title: Integrated assays of single-cell dynamics and molecular phenotype for cell therapy manufacturing
Funded at Cellchorus INC. · NIH-11179716 · Data updated 2026-11-12
This study is working on a new way to closely watch and understand immune cells used in treatments, so we can see how they behave and grow, helping doctors predict how well these therapies might work for patients before they start.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cellchorus INC. NIH-funded |
| Lab location | 1 site (Houston, UNITED STATES) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $984,242 |
| NIH project number | 4R44TR005137-02 |
| Project ID | NIH-11179716 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing or considering cell therapy for various types of cancer.
✕Less likely to help
Patients with conditions not related to cancer or those not eligible for cell therapies may not benefit from this research.
What this research studies
This research focuses on developing an advanced analytical platform to better understand the behavior and characteristics of immune cells used in cell therapies. By utilizing a sophisticated AI-based system, the project aims to track and analyze thousands of cells over time, providing real-time insights into their phenotype and metabolism. This information could help predict the effectiveness of therapies before they are administered to patients, ultimately enhancing treatment outcomes. The approach involves optimizing reagents and protocols to identify key cell attributes and measure their growth potential.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized cell therapies for cancer patients.
How similar studies have gone: Previous research has shown promise in using AI and advanced analytics to improve cell therapy outcomes, indicating a strong potential for success in this approach.
Where this research is happening
-
Cellchorus INC.
Houston, United States Active
Researchers
- Principal investigator: Berdeaux, Rebecca L — Cellchorus INC.
- Study coordinator: Berdeaux, Rebecca L
Related research
Other NIH-funded projects on the same topics.
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LF-TIMING: Large-scale profiling of cell-cell interactions with label-free imaging
A new high-throughput method to map how immune cells talk to tumor cells and how they move, contact, and kill targets without using labels.
-
A new instrument to understand how immune cells work
This project is developing a special instrument that uses advanced imaging and AI to watch individual immune cells in action, helping us understand how they fight diseases like cancer.
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TIMING: AI-powered single-cell analysis to improve cell therapies
A patient-facing platform using AI to understand how individual immune cells behave in real time during cell therapy manufacturing, helping create safer and more effective treatments.
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Dynamic single-cell analysis instrument ready to help labs map how individual cells behave
Aimed at bringing Chronos™—a specialized single-cell timing instrument—into broader use so researchers can watch thousands of live cells and link their behavior to molecular data.
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Advanced Technology to Understand Immune Cell Behavior
This project is creating a new technology that uses advanced imaging and artificial intelligence to better understand how individual immune cells work and interact, which can help develop new treatments.
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Profiling how immune cells interact with tumor cells
This study is testing a new way to look at how immune cells and tumor cells interact, which could help us understand cancer better and improve treatments for patients like you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.