Understanding how immune cells behave in autoimmune diseases
Regulation, function and localization of monocytes in autoimmune tissues
This study is looking at how certain immune cells, called monocytes, behave in autoimmune diseases like lupus nephritis and rheumatoid arthritis, to help us understand their role in inflammation and healing, which could lead to new treatments for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064782 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, particularly monocytes, in autoimmune conditions like lupus nephritis and rheumatoid arthritis. By analyzing RNA from thousands of single immune cells, the team aims to identify unique immune cell states and their functions in disease progression. The study will explore how these monocytes interact with other cells, such as fibroblasts, to understand their contribution to inflammation and tissue repair. Patients may benefit from insights that could lead to new therapeutic strategies targeting these immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autoimmune diseases such as lupus nephritis or rheumatoid arthritis.
Not a fit: Patients with non-autoimmune conditions or those not diagnosed with the specified autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases by targeting specific immune cell functions.
How similar studies have performed: Previous research has shown promise in understanding immune cell behavior in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hacohen, Nir — Brigham and Women's Hospital
- Study coordinator: Hacohen, Nir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.