Understanding how immune cells are activated in lupus
Official title: Investigating monocyte activation pathways in lupus
Funded at Yale University · NIH-11077246 · Data updated 2026-11-12
This study is looking at how the immune system works in people with lupus, especially how certain immune cells can become overactive and cause problems, and it invites patients to help by sharing samples or information to better understand their condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 19, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $357,445 |
| NIH project number | 5R01AR082203-03 |
| Project ID | NIH-11077246 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus.
✕Less likely to help
Patients with other autoimmune diseases or those without a diagnosis of lupus may not benefit from this research.
What this research studies
This research investigates the immune system's response in patients with systemic lupus erythematosus (SLE), focusing on how certain immune cells, particularly monocytes, become activated and contribute to the disease. By examining the pathways that lead to the production of inflammatory molecules, the study aims to uncover the mechanisms behind tissue damage in lupus. Patients may be involved in providing samples or data that help researchers understand the role of these immune responses in their condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even prevent tissue damage in lupus patients.
How similar studies have gone: Previous research has shown promising results in understanding immune pathways in lupus, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Kang, Insoo — Yale University
- Study coordinator: Kang, Insoo
Related research
Other NIH-funded projects on the same topics.
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A doctor-scientist at Yale is studying why certain immune T cells cause skin damage in discoid lupus, with the goal of finding ways to reduce scarring and improve health for patients, especially African American women.
-
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Immunostimulatory short non-coding RNAs and lupus
A study in people with lupus looks at tiny RNA pieces that may spark inflammation, to understand if they drive disease activity.
-
Antiviral factors that limit HIV in people with SLE
Researchers at Howard University are studying how immune factors in people with lupus may help limit HIV infection.
-
PTPRS and lupus nephritis: a new target to reduce kidney damage in lupus
Aims to understand how PTPRS contributes to kidney inflammation and scarring in lupus nephritis and explore targeting it to help patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.