Understanding how immune cells and nerves interact in the cornea
Mechanisms of Corneal Neuro-Immune Crosstalk
['FUNDING_R01'] · TUFTS MEDICAL CENTER · NIH-11051056
This study is looking at how immune cells and sensory nerves in the eye work together, especially for people with neurotrophic keratitis, a condition that can harm vision due to nerve damage, to find new ways to help these nerves heal and improve treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11051056 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between immune cells and sensory nerves in the cornea, particularly focusing on neurotrophic keratitis, a condition that threatens vision due to nerve damage. The study aims to identify specific ligand-receptor pairs that facilitate communication between these cells, which may help in understanding how to support nerve survival and regeneration. By analyzing these interactions, the research seeks to develop new diagnostic and treatment strategies for patients suffering from corneal nerve dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing corneal hypoesthesia or neurotrophic keratitis due to nerve injury or dysfunction.
Not a fit: Patients with intact corneal nerve function or those with unrelated ocular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore nerve function and improve vision in patients with neurotrophic keratitis.
How similar studies have performed: Previous research has shown promising results in understanding nerve-immune interactions, suggesting that this approach could yield valuable insights and advancements.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAMRAH, PEDRAM — TUFTS MEDICAL CENTER
- Study coordinator: HAMRAH, PEDRAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.