Understanding how immune cells and nerves interact during dental pulp inflammation and pain
Roles of neutrophil-sensory neuron interactions in dental pulp inflammation and pain
This study is looking at how certain immune cells called neutrophils interact with nerve cells during dental pulp inflammation, which can cause pain, to help find better ways to manage pain for dental patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11035091 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between neutrophils, a type of immune cell, and sensory neurons in the context of dental pulp inflammation, known as pulpitis. By using advanced animal models and various imaging techniques, the study aims to uncover how these interactions contribute to pain and inflammation in the dental pulp and surrounding tissues. The principal investigator will explore the role of neutrophils in nerve injury and how they influence pain outcomes, potentially leading to new pain management strategies for dental patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing dental pulp inflammation or pain, particularly those with pulpitis.
Not a fit: Patients with dental issues unrelated to pulpitis or those who do not experience pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for dental pain, reducing the need for invasive procedures like root canals.
How similar studies have performed: Previous research has shown promise in understanding immune-neuron interactions in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Erdogan, Ozge — Harvard Medical School
- Study coordinator: Erdogan, Ozge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.