Understanding how immune cells and fibrosis interact in corneal transplants
The Fibrosis-Immunity Interface in Corneal Transplantation
['FUNDING_CAREER'] · MASSACHUSETTS EYE AND EAR INFIRMARY · NIH-10862803
This study is looking at how certain immune cells called T cells and a type of cell that can cause scarring in the eye work together, especially during corneal transplants, to find ways to improve healing and prevent transplant failures, which could help patients have better outcomes after their surgery.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS EYE AND EAR INFIRMARY (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10862803 on ClinicalTrials.gov |
What this research studies
This research investigates the complex relationship between T cell immunity and fibrosis in the cornea, particularly in the context of corneal transplantation. The project aims to identify how T cells contribute to fibrosis and how myofibroblasts can suppress T cell activity, potentially leading to improved transplant outcomes. By exploring these mechanisms, the research seeks to develop new therapeutic strategies to prevent transplant failure and enhance healing. Patients may benefit from insights that could lead to better management of corneal transplant procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are considering or have undergone corneal transplantation and may be at risk for fibrosis-related complications.
Not a fit: Patients who do not require corneal transplantation or have conditions unrelated to corneal fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for patients undergoing corneal transplantation by reducing the risk of transplant failure.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in transplantation, suggesting that this approach may yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS EYE AND EAR INFIRMARY — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOHLMAN, THOMAS — MASSACHUSETTS EYE AND EAR INFIRMARY
- Study coordinator: DOHLMAN, THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.