Understanding how immune cells and fibroblasts interact to improve treatment for pancreatic cancer
Official title: Disrupting MDSC-fibroblast interactions to overcome chemoimmunotherapy resistance in pancreatic cancer
Funded at University of Miami School of Medicine · NIH-10944920 · Data updated 2026-11-12
This study is looking at how certain immune cells and supporting cells in pancreatic cancer work together to make treatments like chemotherapy and immunotherapy less effective, with the hope of finding new ways to improve these treatments for patients.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 28, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $351,131 |
| NIH project number | 1R37CA292843-01 |
| Project ID | NIH-10944920 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with pancreatic ductal adenocarcinoma who are undergoing or considering chemotherapy or immunotherapy.
✕Less likely to help
Patients with other types of cancer or those who are not receiving chemotherapy or immunotherapy may not benefit from this research.
What this research studies
This research investigates the interactions between specific immune cells and fibroblasts in pancreatic cancer, which contribute to resistance against chemotherapy and immunotherapy. By examining the signaling pathways involved, the study aims to uncover how these interactions promote tumor growth and hinder effective treatment. The approach includes analyzing tumor samples and utilizing advanced techniques to disrupt these harmful interactions, potentially leading to more effective therapies for patients. The goal is to enhance the effectiveness of existing treatments by targeting the mechanisms that allow tumors to evade therapy.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with pancreatic cancer, potentially increasing survival rates.
How similar studies have gone: Previous research has shown promise in targeting immune cell interactions in cancer treatment, suggesting that this approach could yield significant advancements.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Datta, Jashodeep — University of Miami School of Medicine
- Study coordinator: Datta, Jashodeep
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.