Understanding how immune cells and fibroblasts help heal lung injuries
Lung repair mechanisms mediated by the immune-fibroblast interface
This study is looking at how immune cells and lung cells work together to heal after lung injuries, which could help us find new treatments for lung problems that some patients face.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10876267 on NIH RePORTER |
What this research studies
This research investigates the interactions between immune cells and fibroblasts in the lungs to understand how they contribute to healing after lung injuries. It focuses on how these cells communicate and signal each other during the repair process, especially after exposure to harmful substances or infections. By using advanced genetic mouse models and organoid systems, the research aims to uncover the molecular pathways involved in lung repair and how dysfunctional cells may lead to chronic lung diseases. Patients may benefit from insights gained that could lead to new treatments for lung injuries and diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced lung injuries or suffer from chronic lung conditions.
Not a fit: Patients with stable, non-progressive lung diseases or those without any history of lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung healing and improve outcomes for patients with lung injuries or chronic lung diseases.
How similar studies have performed: Previous research has shown promising results in understanding immune and fibroblast interactions in other tissues, suggesting potential for success in this novel approach for lung repair.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Zepp, Jarod — Children's Hosp of Philadelphia
- Study coordinator: Zepp, Jarod
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.