Understanding how immune cells affect lung transplant rejection and dysfunction
Loss of resident donor-derived Tregs and the emergence of monocyte-derived alveolar macrophages leads to acute rejection and chronic dysfunction in lung transplant recipients
['FUNDING_FELLOWSHIP'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10994449
This study is looking at how certain immune cells in the lungs might affect the health of lung transplant patients over time, with the goal of finding ways to help them avoid problems and improve their recovery.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10994449 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific immune cells, particularly monocyte-derived alveolar macrophages, in the development of chronic lung allograft dysfunction (CLAD) in lung transplant recipients. By analyzing clinical and molecular biomarkers, the study aims to identify pathways that could be targeted for intervention to improve patient outcomes. The approach includes leveraging machine learning to analyze longitudinal data collected from patients before the onset of CLAD, which may provide insights into the progression of the condition. This research seeks to enhance our understanding of how immune responses contribute to lung transplant success and failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone lung transplantation and are at risk for developing chronic lung allograft dysfunction.
Not a fit: Patients who have not received a lung transplant or those who are not at risk for CLAD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating chronic dysfunction in lung transplant recipients.
How similar studies have performed: Previous research has shown promising results in understanding immune cell roles in transplant rejection, suggesting that this approach may yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUO, LUCY — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: LUO, LUCY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.