Understanding how immune cells affect lung inflammation in cystic fibrosis
Official title: The Role of Macrophage Metabolic Crosstalk in CF Chronic Lung Inflammation
Funded at Dartmouth-Hitchcock Clinic · NIH-10930185 · Data updated 2026-11-12
This study is looking at how a type of immune cell called macrophages acts differently in people with cystic fibrosis compared to those without it, to better understand the ongoing lung inflammation in CF and find new ways to help improve lung health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project start | September 23, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $637,263 |
| NIH project number | 1R56HL158923-01A1 |
| Project ID | NIH-10930185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cystic fibrosis who experience chronic lung inflammation.
✕Less likely to help
Patients without cystic fibrosis or those whose lung inflammation is not related to macrophage activity may not benefit from this research.
What this research studies
This research investigates the role of macrophages, a type of immune cell, in the chronic lung inflammation experienced by patients with cystic fibrosis (CF). It focuses on how these macrophages behave differently in CF compared to non-CF conditions, particularly looking at their metabolism and inflammatory responses. The study aims to uncover the mechanisms behind persistent inflammation in the lungs of CF patients, which could lead to new therapeutic strategies. By analyzing the interactions between different types of macrophages and their metabolic processes, the research seeks to identify potential targets for improving lung health in CF.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce chronic lung inflammation and improve respiratory health for patients with cystic fibrosis.
How similar studies have gone: Previous research has shown that targeting immune cell behavior can lead to significant improvements in managing chronic inflammatory conditions, suggesting potential success for this approach.
Where this research is happening
-
Dartmouth-Hitchcock Clinic
Lebanon, United States Active
Researchers
- Principal investigator: Ashare, Alix — Dartmouth-Hitchcock Clinic
- Study coordinator: Ashare, Alix
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.