Understanding how immune cells affect liver disease progression
Macrophage Mitochondrial Pyruvate Carrier in Nonalcoholic Steatohepatitis
['FUNDING_CAREER'] · WASHINGTON UNIVERSITY · NIH-11058471
This study is looking at how certain immune cells in the liver, called macrophages, change when someone has nonalcoholic steatohepatitis (NASH), a serious liver condition, to help find new ways to treat it and prevent complications.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11058471 on ClinicalTrials.gov |
What this research studies
This research focuses on nonalcoholic steatohepatitis (NASH), a serious liver disease that can lead to severe complications like cirrhosis and liver cancer. The study aims to explore the role of macrophages, a type of immune cell, in the progression of NASH by examining how these cells change their function and metabolism in response to liver damage. By identifying the mechanisms that influence macrophage behavior, the research seeks to uncover potential new treatments for NASH and its related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with nonalcoholic steatohepatitis who are at risk for liver-related complications.
Not a fit: Patients with liver diseases unrelated to nonalcoholic steatohepatitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating nonalcoholic steatohepatitis and improving liver health.
How similar studies have performed: Previous research has shown promising results in understanding immune cell roles in liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FERGUSON, DANIEL — WASHINGTON UNIVERSITY
- Study coordinator: FERGUSON, DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.