Understanding how immune cells affect kidney transplant success
Monocyte and Macrophage Functional Evolution in Kidney Transplantation
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10994275
This study is looking at how certain immune cells in your body, called monocytes and macrophages, behave after a kidney transplant to help us understand why some transplants succeed while others fail, with the hope of finding better ways to improve transplant success and reduce the chances of needing another transplant.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10994275 on ClinicalTrials.gov |
What this research studies
This research investigates the role of monocytes and macrophages in kidney transplantation, focusing on how these immune cells evolve and respond after a transplant. By studying the infiltration of monocytes and their transformation into macrophages, the research aims to identify factors that contribute to both early and late graft failures. The approach includes examining specific proteins that influence immune responses and fibrosis in the kidney, with the goal of finding ways to improve transplant outcomes and reduce the need for re-transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals undergoing kidney transplantation or those with end-stage kidney disease.
Not a fit: Patients who are not candidates for kidney transplantation or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing kidney transplant rejection and enhancing long-term graft survival.
How similar studies have performed: Previous studies have shown promising results in understanding immune responses in kidney transplants, indicating that this approach has potential for success.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUO, XUNRONG — DUKE UNIVERSITY
- Study coordinator: LUO, XUNRONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.