Understanding how immune cells affect kidney transplant success
Epigenetic Regulation of Regulatory B Cell Cytokine Expression and Allograft Rejection
This study is looking at how certain immune cells in your body might help doctors predict how well a kidney transplant will work for you, so they can create more tailored treatment plans to improve your chances of success.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10983782 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as regulatory B cells, in kidney transplant outcomes. It focuses on how the expression of certain cytokines, particularly IL-10 and TNFα, can predict the risk of acute rejection and long-term graft survival. By analyzing blood samples from patients before and after transplantation, the study aims to identify biomarkers that can help doctors assess the likelihood of transplant success. This could lead to more personalized treatment plans for kidney transplant recipients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are undergoing kidney transplantation.
Not a fit: Patients who are not undergoing kidney transplantation or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and preventing kidney transplant rejection, enhancing patient outcomes.
How similar studies have performed: Previous research has shown promise in using immune cell biomarkers to predict transplant outcomes, suggesting that this approach could be effective.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Cherukuri, Aravind — University of Pittsburgh at Pittsburgh
- Study coordinator: Cherukuri, Aravind
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.