Understanding how immune cells affect intestinal stem cells during GI damage
T cell invasion of the stem cell compartment during immune-mediated GI damage
This study is looking at how the immune system affects the cells that help repair the intestines, especially when patients have complications after a bone marrow transplant, and it hopes to find ways to improve treatments for those patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10756493 on NIH RePORTER |
What this research studies
This research investigates the interactions between the immune system and intestinal stem cells (ISCs) in the gastrointestinal tract, particularly during immune-mediated damage such as graft vs. host disease (GVHD) following bone marrow transplantation. The study aims to explore how immune responses can lead to damage in the ISC compartment and how these interactions can be manipulated for therapeutic purposes. By examining the three-dimensional tissue environment of the intestines, the research seeks to uncover the mechanisms behind ISC damage and regeneration, which could inform better treatment strategies for patients undergoing transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing allogeneic hematopoietic/bone marrow transplantation who are at risk for gastrointestinal complications.
Not a fit: Patients with gastrointestinal issues unrelated to immune-mediated damage or those not undergoing bone marrow transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from severe gastrointestinal complications following bone marrow transplantation.
How similar studies have performed: Previous research has shown promising results in understanding immune interactions in other contexts, but this specific approach to studying ISCs in relation to GVHD is relatively novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Hanash, Alan M — Sloan-Kettering Inst Can Research
- Study coordinator: Hanash, Alan M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.