Understanding how immune cells affect HIV-related immune dysfunction
Control of HIV-induced MDSC expansion and immunosuppression by cytotoxic lymphocytes
This study is looking at how certain immune cells might be making it harder for people with HIV to recover their immune system while on treatment, and it hopes to find new ways to help boost their immune health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-10935398 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as granulocytic myeloid-derived suppressor cells (PMN-MDSCs), in causing immune dysfunction in individuals living with HIV. The study aims to understand how these cells impact the recovery of CD4+ T cells and the overall immune response, particularly in the context of combined antiretroviral therapy (cART). By exploring the mechanisms that lead to elevated PMN-MDSC levels and their effects on other immune cells, the research seeks to identify potential therapeutic targets to improve immune function in HIV patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing immune dysfunction despite receiving antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who have well-controlled immune function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance immune recovery and function in individuals living with HIV.
How similar studies have performed: Other research has shown promising results in targeting immune cells for therapeutic purposes, suggesting that this approach may hold potential for improving outcomes in HIV treatment.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Paust, Silke — Jackson Laboratory
- Study coordinator: Paust, Silke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.