Understanding how immune cells affect heart health and failure
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart Failure
This study is looking at how certain immune cells in your body, called macrophages, affect heart failure, with the hope of finding new ways to help improve heart health for people with heart conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10997314 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, particularly macrophages, in the development and progression of heart failure. By examining how these cells contribute to inflammation and cardiac remodeling, the study aims to uncover new therapeutic targets for improving heart health. The approach involves analyzing immune cell behavior and signaling mechanisms in the heart, which could lead to better treatment strategies for patients with heart conditions. Patients may benefit from insights that could inform future therapies aimed at reducing inflammation and improving heart function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with heart failure or those who have experienced a myocardial infarction.
Not a fit: Patients with non-cardiac related health issues or those without any history of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promise in targeting immune responses in cardiovascular diseases, indicating a potential for success in this area.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Lavine, Kory J. — Washington University
- Study coordinator: Lavine, Kory J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.