Understanding how immune cells affect gut healing in inflammation
Intestinal Inflammation: Signaling proteins and the rate of PMN transmigration
This research explores how immune cells and gut lining cells work together during inflammation, like in Inflammatory Bowel Disease, to understand how the gut heals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11085077 on NIH RePORTER |
What this research studies
When the gut becomes inflamed, as seen in conditions like Inflammatory Bowel Disease (IBD), the body's immune response can sometimes cause more harm than good, making it harder for the gut to heal. This project aims to understand how certain immune cells, called neutrophils, interact with the cells lining the intestine during both inflammation and the healing process. We are looking closely at specific proteins, like CD47, TSP1, and LTB4, which act as signals between these cells. By studying these signals, we hope to uncover the mechanisms that control how the gut repairs itself after injury. This knowledge could lead to new ways to help the gut heal more effectively.
Who could benefit from this research
Good fit: This research is relevant for patients living with inflammatory bowel diseases (IBD) and other conditions involving gut inflammation and impaired healing.
Not a fit: Patients without conditions involving intestinal inflammation or wound repair issues would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help the gut heal better in patients with inflammatory conditions like IBD.
How similar studies have performed: This project builds upon preliminary data and previous studies by the research group and others, indicating a foundation of prior work in this area.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Parkos, Charles a — University of Michigan at Ann Arbor
- Study coordinator: Parkos, Charles a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.