Understanding how immune cells affect breast cancer outcomes
Official title: Characterization of the metastatic TIME by subcellular spatial profiling
Funded at Baylor College of Medicine · NIH-10949934 · Data updated 2026-11-12
This study is looking at how certain immune cells in the body affect the growth of triple negative breast cancer after chemotherapy, with the hope of finding new treatments that can help patients feel better and fight the disease more effectively.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $125,000 |
| NIH project number | 1K99GM155594-01 |
| Project ID | NIH-10949934 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American women diagnosed with triple negative breast cancer who are undergoing or have undergone chemotherapy.
✕Less likely to help
Patients with non-triple negative breast cancer or those who do not have metastatic disease may not benefit from this research.
What this research studies
This research investigates the role of immune cells, particularly macrophages and tumor-infiltrating lymphocytes, in the progression of triple negative breast cancer (TNBC) after chemotherapy. By using genetically engineered mouse models that mimic the aggressive characteristics of TNBC, the study aims to explore how these immune cells interact within the tumor microenvironment and influence treatment resistance. The goal is to identify potential therapies that could improve patient outcomes by targeting these immune interactions in metastatic disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response against breast cancer, potentially improving survival rates for patients.
How similar studies have gone: Previous research has shown promising results in targeting immune cells to improve cancer treatment outcomes, suggesting that this approach may be effective.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Pedroza, Diego a — Baylor College of Medicine
- Study coordinator: Pedroza, Diego a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.