Understanding how immune cells affect brain recovery after injury
Role of Myeloid And CD4+ T Immune Cells in Post-Traumatic Plasticity
This study is looking at how certain immune cells in the brain help it heal after a traumatic brain injury, and it’s for anyone interested in understanding why some people experience problems with thinking, sleep, or seizures after such injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10992152 on NIH RePORTER |
What this research studies
This research investigates the role of immune cells, specifically myeloid and CD4+ T cells, in the brain's recovery process following traumatic brain injury (TBI). By examining how these immune cells interact with neural circuits, the study aims to uncover the mechanisms behind cognitive dysfunction, sleep disturbances, and the development of epilepsy that often follow TBI. The research utilizes advanced imaging techniques to observe changes in brain structure and function over time, providing insights into the inflammatory processes that contribute to these neurological issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are facing cognitive or sleep-related challenges.
Not a fit: Patients with brain injuries that are not recent or those who do not exhibit cognitive dysfunction or sleep disturbances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve recovery and quality of life for individuals affected by traumatic brain injuries.
How similar studies have performed: Previous research has shown that understanding the role of immune cells in brain recovery can lead to significant advancements in treatment strategies for brain injuries.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Paz, Jeanne T — J. David Gladstone Institutes
- Study coordinator: Paz, Jeanne T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.